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A TRANSFORMULATION of topical clobetasol that patients can appreciate

DIRECTIONS FOR USE: Apply a thin layer of IMPOYZ cream to the affected skin area twice daily and rub in gently and completely. Approved for use for up to 2 consecutive weeks of treatment.1
Enhanced permeation with no effect on the skin's lamellar structure2

  • The ingredient diethylene glycol monoethyl ether (Transcutol*) enhances permeation with effectiveness comparable comparable to clobetasol propionate 0.05%.2,3

  • Propylene glycol, commonly used in other formulations which can impact the skin's lamellar structure, already disturbed by psoriasis.3,4

  • The most common side effect of Impoyz Cream includes discoloration of the treated site. This is not the only possible side effect of Impoyz Cream.1

  • Impoyz Cream can cause reversible hypothalamic-pituitary-arenal (HPA) axis suppression with the potential for glucocosticosteroid insufficiency.2
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IMPOYZ® (clobetasol propionate) Cream 0.025% is indicated for the treatment of moderate to severe plaque psoriasis in patients 18 years of age and older.1

Warnings and Precautions
Local Adverse Reactions: Local adverse reactions with topical corticosteriods may occur more frequently with the use of occlusive dressings, prolonged use, or use of high potency corticosteroids, including clobetasol propionate. These reactions include: irritation, dryness, acneiform eruptions, hypertrichosis, hypopigmentation, perioral dermatitis, allergic contact dermatitis, allergic contact dermatitis, secondary infection, striae, miliaria.1

Adverse Reactions
The most common adverse reactions (incidence > 1%) is application site discoloration.

Dosage and Administration
  • Apply a thin layer of IMPOYZ Cream to the affected skin area twice daily and rub in gently and completely. Wash hands after each application. Use IMPOYZ Cream for up to 2 consecutive weeks of treatment.
  • Discontinue IMPOYZ Cream when control is achieved.
  • The total dosage should not exceed 50 g per week.
  • Do not use if atrophy is present at the treatment site.
  • Do not bandage, cover up, or wrap the treated skin area unless directed by a physician.
  • Avoid use on the face, scalp, axilla, groin, or other intertriginous areas.
  • IMPOYZ Cream is for topical use only. It is not for oral, ophthalmic, or intravaginal use.
Please click to download full Prescribing Information.

1. Impoyz [package insert] Primus Pharmaceuticals, Inc. 2021.
2. Draelos Z, et al. A Randomized, Parallel Group, Open Label, Multicenter Study to Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing with Clobetasol Propionate Cream (Impoyz® ), 0.025% versus Clobetasol Propionate (Temovate®) Cream, 0.05% in Subjects with Moderate to Severe Plaque Psoriasis. Skin. 2018. 2:(6)410-420.
3. Trivedi K et al. Development of Novel Microemulsion Based Topical Formulation of Clobetasol Propionate and Salicylic Acid for The Treatment of Psoriasis. Int. Res. J. Pharm. 2018;9 (5).
4. Ghadially R, et al. Stratum Corneum Structure and Function Correlates with Phenotype in Psoriasis. Invest Dermatol. 1996; 107:558-564.